Tools & Techniques Cancer

Proceed With Caution

| Shyamala Maheswaran

Two recent studies on EMT may revise the field’s understanding of the process – but it’s important to keep in mind the limitations.

Outside the Lab Cancer

Oncogenetic Pioneer

| Robert A. Weinberg

Sitting Down With… Robert A. Weinberg, founding member of the Whitehead Institute for Biomedical Research and Professor of Biology at the Massachusetts Institute of Technology, USA.

Outside the Lab Cancer

Cancer Control on a Shoestring

| Rengaswamy Sankaranarayanan

As cancer rates continue to climb, low and middle income countries are ramping up prevention and screening efforts.

Disease Area Cancer

In Good Company

| Bharathi Vennapusa

What does it take to create a competitive companion diagnostic? Bharathi Vennapusa outlines her role in the development and approval of the ALK CDx – a fully-automated immunohistochemistry assay that identifies lung cancer patients who may be eligible for treatment with Pfizer’s Xalkori (crizotinib).

Research Field Genetics

Ghost in the Cell

| William Aryitey

New software couples computer programming with cell function using the ultimate coding language: DNA

Research Field Drug discovery

Arresting ALS

| Joe Beckman

When it comes to prognosis, the mouse models I use to study amyotrophic lateral sclerosis (ALS) are sadly accurate – like their human counterparts with familial ALS, all mice with these mutations die young. After 20 years of trying – and failing – to find a treatment that could extend life, I was close to giving up, until a new drug candidate came along. Then something amazing happened – a mouse lived.

Tools & Techniques Cancer

Cells on the (Invasion) Front Lines

| Michael Schubert

Long thought to be a key component of the metastatic process, researchers are now questioning long-held beliefs on the role of the epithelial-to-mesenchymal transition.

Tools & Techniques Animal models

Lost in Translation?

| Pascal Sanchez, Steve Finkbeiner, Kate Possin

Scientists from opposite ends of the translational spectrum have teamed up to help solve a pressing problem in Alzheimer’s research. By creating a human equivalent to the water mazes used in rodent studies, they hope to allow easier comparison of data from animal and human studies.

Tools & Techniques Public health

On the Spot Diagnosis

| Laura Lechuga

Mobile devices promise a new future of point-of-care diagnostics for all

Outside the Lab Professional development

Perfect Partners?

| Abhay Pandit

When it comes to industry–academia partnerships, it’s quality – not quantity – that counts.

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