Like most websites The Translational Scientist uses cookies. In order to deliver a personalized, responsive service and to improve the site, we remember and store information about how you use it. Learn more.
Research Field Drug discovery, Genetics

Arresting ALS

Every day I receive emails from ALS patients and their loved ones, which is both gratifying and heart breaking. The time from onset of the disease to death can be just a few years, and patients are desperate for some hope. The possibility that my work might help these people is a large part of what has kept me going for over 20 years, despite all the setbacks and frustrations.

My ALS journey actually started with an interest in oxidative stress. I was studying the oxidant peroxynitrite, which mediates tyrosine nitration – a process you can find in stroke, diabetes, heart disease, neurodegenerative disorders and many other conditions. One of the major antioxidant defenses that prevents the formation of peroxynitrite and protects the body from oxidative stress is the protein superoxide dismutase (SOD). But SOD also has a dark side – we discovered that it can catalyze tyrosine nitration, speeding up oxidative damage.

Read the full article now

Log in or register to read this article in full and gain access to The Translational Scientist’s entire content archive. It’s FREE and always will be!


Or register now - it’s free and always will be!

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts

Or Login via Social Media

By clicking on any of the above social media links, you are agreeing to our Privacy Notice.

About the Author

Joe Beckman

Joe Beckman is the Principle Investigator, and Burgess and Elizabeth Jamieson Chair, in Healthspan Research at the Linus Pauling Institute, Oregon State University.

Related Solutions

Research Field Drug discovery

Dental Curing Lights: Clinical Reality

| Contributed by Ocean Optics

Research Field Genetics

Measuring DNA Absorbance with the STS-UV

| Contributed by Ocean Optics

Related Articles

Research Field Cancer

Cancer and the Microbiome

| Ivan Gladwyn-Ng, Alexander Maue

Research Field Neurological

Redirecting Cell Fate

| Jonathan James

Disease Area Cancer

Two-pronged Attack on Neuroblastoma

| Jonathan James

Register to The Translational Scientist

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts