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The Translational Scientist
This month we ask top pain researchers why it has proven so hard to translate promising targets into much–needed new painkillers. Upfront has everything from fly eyes, to night vision for cells, plus we discover the origins of rage (at least in mice). Toolbox focuses on detecting protein conformational changes, and fragment screening by X-ray crystallography. This month’s Translated case study follows the 20-year journey to a vaccine for dengue – otherwise known as breakbone fever. Finally, we sit down with John Doench, the Broad Institute’s gene genie.