Cookies

Like most websites The Translational Scientist uses cookies. In order to deliver a personalized, responsive service and to improve the site, we remember and store information about how you use it. Learn more.
Tools & Techniques Diagnostics & prognostics, Analytical science

Analyzing Humanity

The Humanity in Science Award – a collaboration between chromatography company Phenomenex and our sister publication The Analytical Scientist – recognizes breakthroughs in analytical science that have the potential to improve human lives.  As the stories below show, accurate analysis is at the heart of successful clinical translation, and can even help get the right medicines to the people who need them.  Twelve months on, we find out what three teams have been doing since – and ask why “humanity” is such a fundamental part of what they do.

Critical Translation:

Don Farthing

Could you briefly describe your work?

Our translational research focuses on the critical medical need for a new biomarker and analytical method for rapidly detecting acute cardiac ischemia, at the very early onset of a heart attack. Using HPLC and mass spectrometry techniques, we determined that plasma inosine and hypoxanthine were promising candidate biomarkers for indicating acute cardiac ischemia. However, LC-MS technology does not easily lend itself to use in or outside of the hospital emergency room environment. Therefore, we developed a rapid and sensitive chemiluminescence test for use on a microplate luminometer, which can qualitatively determine plasma levels of inosine and hypoxanthine in less than a minute.

Our group at VCU Medical Center performed preclinical research using a mouse model of cardiac ischemia, followed by human sample evaluations from ER non-traumatic chest pain patients. Clinical studies are ongoing to evaluate hospital cardiac patient plasma inosine and hypoxanthine levels, in conjunction with cardiac troponin levels, to better understand their diagnostic potential for alerting cardiac ischemia, several hours prior to the markers of ischemia-induced heart tissue necrosis being released into the blood stream of the heart attack patients. If inosine and hypoxanthine are clinically validated for diagnoses, their use and the rapid chemiluminescence test can potentially save thousands of lives, as well as millions of dollars in hospital costs each year. The ultimate goal of this translational research is to miniaturize the US patented chemiluminescence test, for use in a point-of-care handheld medical device.

Read the full article now

Log in or register to read this article in full and gain access to The Translational Scientist’s entire content archive. It’s FREE and always will be!

Login if you already created an account

Or register now - it’s free and always will be!

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
Register

Or Login as a Guest or via Social Media

Newsletter

Send me the latest from The Translational Scientist.

Sign up now

Related Articles

Disease Area Cancer

Load Versus Response

| Jonathan James

Disease Area Neurological

Alzheimer's Awakening

| Jonathan James

Tools & Techniques Diagnostics & prognostics

IAs - ID'd

| Jonathan James

Most Popular

Register to The Translational Scientist

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts

Register