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Diagnostics & prognostics

Tools & Techniques Cancer

Cancer Fighter PILOT

| Charlotte Barker

A novel PDX screening technique has uncovered new molecular drivers for PDAC

Tools & Techniques Cancer

The PDAC Key

| Michael Schubert

Pancreatic cancer cells don’t seem to rely on EMT for metastasis – but it plays a key role in their ability to resist our best chemotherapy options

Tools & Techniques Cancer

Tracking the Transition

| Dingcheng Gao

A triple-transgenic mouse model allows researchers to trace the lineage of EMT tumor cells, and reveals the transition’s surprising lack of significance in metastasis

Tools & Techniques Cancer

Proceed With Caution

| Shyamala Maheswaran

Two recent studies on EMT may revise the field’s understanding of the process – but it’s important to keep in mind the limitations.

Disease Area Cancer

In Good Company

| Bharathi Vennapusa

What does it take to create a competitive companion diagnostic? Bharathi Vennapusa outlines her role in the development and approval of the ALK CDx – a fully-automated immunohistochemistry assay that identifies lung cancer patients who may be eligible for treatment with Pfizer’s Xalkori (crizotinib).

Tools & Techniques Cancer

Cells on the (Invasion) Front Lines

| Michael Schubert

Long thought to be a key component of the metastatic process, researchers are now questioning long-held beliefs on the role of the epithelial-to-mesenchymal transition.

Tools & Techniques Public health

On the Spot Diagnosis

| Laura Lechuga

Mobile devices promise a new future of point-of-care diagnostics for all

Tools & Techniques Omics

Clinical Translation Through Innovation

| Thomas Conrads

Advances in mass spectrometry and separation science are bringing genome-scale proteomic analyses within our reach.

Tools & Techniques Omics

Disrupting Cytogenetics in the Clinic

| George Vasmatzis

To select the right treatment for each cancer patient, we need fast, accurate and cost-effective ways to characterize tumors. Now, with newly developed algorithms and protocols, mate pair sequencing could well be the tool we’ve been seeking.

Tools & Techniques Drug discovery

A Story of Shared Science and Solutions

| Niclas Nilsson

Pharma companies are notoriously protective of their intellectual property, so it’s a big deal to open up and give knowledge away for free.

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