Diagnostics & prognostics

A triple-transgenic mouse model allows researchers to trace the lineage of EMT tumor cells, and reveals the transition’s surprising lack of significance in metastasis

Two recent studies on EMT may revise the field’s understanding of the process – but it’s important to keep in mind the limitations.

What does it take to create a competitive companion diagnostic? Bharathi Vennapusa outlines her role in the development and approval of the ALK CDx – a fully-automated immunohistochemistry assay that identifies lung cancer patients who may be eligible for treatment with Pfizer’s Xalkori (crizotinib).

Long thought to be a key component of the metastatic process, researchers are now questioning long-held beliefs on the role of the epithelial-to-mesenchymal transition.

Mobile devices promise a new future of point-of-care diagnostics for all

Advances in mass spectrometry and separation science are bringing genome-scale proteomic analyses within our reach.

To select the right treatment for each cancer patient, we need fast, accurate and cost-effective ways to characterize tumors. Now, with newly developed algorithms and protocols, mate pair sequencing could well be the tool we’ve been seeking.

Pharma companies are notoriously protective of their intellectual property, so it’s a big deal to open up and give knowledge away for free.

Identifying babies at risk of deadly gastrointestinal disease through microbiomics

As the judges deliberate over this year's winner, we speak with three of the top-placed entrants from the 2015 Humanity in Science Award.