Drug discovery

A more efficient way to develop 'one-handed' drug molecules

iPSCs could protect patients by predicting drug-induced cardiotoxicity

When it comes to prognosis, the mouse models I use to study amyotrophic lateral sclerosis (ALS) are sadly accurate – like their human counterparts with familial ALS, all mice with these mutations die young. After 20 years of trying – and failing – to find a treatment that could extend life, I was close to giving up, until a new drug candidate came along. Then something amazing happened – a mouse lived.

Are the metrics used to measure cancer drug efficacy inherently flawed?

Pharma companies are notoriously protective of their intellectual property, so it’s a big deal to open up and give knowledge away for free.

How can we get cytotoxic drugs through the blood–brain barrier – without permanent damage?

The XChem facility offers drug discovery scientists streamlined, highly sensitive fragment screening, by harnessing the power of synchrotron light.

A new technique allows scientists to see conformational changes caused by ligand binding in real time, opening up new screening options for drug discovery.

A decade after Shinya Yamanaka brought us induced pluripotent stem cells, our ability to generate an endless supply of human heart cells is being put to good use in research and development.

The human immunodeficiency virus has evaded the best efforts of vaccine developers for over three decades.