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May 2017 Issue of The Translational Scientist

Welcome to the June issue of The Translational Scientist! This month, we take a look at two projects working to use circulating tumor DNA to better diagnose and understand cancer, and cover a medical cold case that led to a new molecular therapy. With many more articles appearing online this month, keep an eye on the website for more of the latest news and views in translational science.

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Articles featured in this issue

Research Field Clinical trials

From Acne to MS

| Roisin McGuigan

A recent clinical trial finds a new use for an old antibiotic.

Tools & Techniques Analytical science

The Importance of Chiral Metabolomics

| Tomonori Kimura

Could chiral amino acids function as biomarkers for kidney disease?

Tools & Techniques Cancer

CEA: Overlooked and Underused

| Roisin McGuigan

Could an existing blood test improve treatment choices – and outcomes – for some colon cancer patients?

Research Field Cell & gene therapy

From Bench to Bedside and Back Again

| Roisin McGuigan

Sitting Down With... James Wilson, Professor and Director, Rose H. Weiss Orphan Disease Center.

Outside the Lab Animal models

Pulling Back the Pre-Clinical Curtain

| William Aryitey

Are mouse models the best option we have?

Tools & Techniques Cancer

Getting Smart with Clinical Trials

| Joy Yucaitis

Liquid biopsy technology could help boost clinical trial success.

Disease Area Biomedical engineering

How to Disappear Completely

| Roisin McGuigan

Developing stents for coronary artery disease that don’t outstay their welcome.

Tools & Techniques Cell & gene therapy

Stem Cell Stepping Stones

| Roisin McGuigan

A new treatment for STAT1 mutations has a disappointingly low success rate – but shows potential.

Disease Area Drug discovery

Targeting Tuberculosis

| Santiago Ramón-García

Existing drugs can – and should – be repurposed to fight neglected diseases.

Research Field Omics

Embracing the Proteogenomic Toolkit

| Andreas Hühmer

To win the war on cancer, we need to put proteomics on an equal footing with genomics.

Disease Area Public health

Hurdles to HIV Survival

| Roisin McGuigan

Why are so many patients with HIV still dying too young?

Tools & Techniques Genetics

Metabolic Mystery Revealed

| Michael Schubert

A new GWAS shows that anorexia nervosa is not purely psychiatric – metabolic factors also play a role.

Research Field Diagnostics & prognostics

Cracking a Cold Case

| Roisin McGuigan

A 30-year-old medical puzzle leads researchers to develop a new molecular therapy.

Tools & Techniques Cancer

The Rise of ctDNA, Part Two

| Michael Schubert

Circulating tumor DNA profiling can yield new insights into early-stage lung cancer evolution.

Tools & Techniques Cancer

The Rise of ctDNA, Part One

| Roisin McGuigan

New ctDNA assays could make more metastatic melanoma cases detectable.

Other issues of 2017