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Outside the Lab Animal models, Genetics, Professional development

Pulling Back the Pre-Clinical Curtain

The pre-clinical mouse model is an essential part of many translational medicine journeys, providing preliminary efficacy results that often determine if treatments are able to make the leap into clinical trials. With the growing availability of tools and techniques for genetic recombination, mouse models appear to allow access to increasingly relevant results... or do they? Some researchers argue that alternatives to animal models are overdue, others believe that they’re still the best pre-clinical option.

Can we gain more insight about the effectiveness of modern mouse models by ‘pulling back the curtain’ to see how these living pre-clinical pathways are created? Here, we speak with John Couse, portfolio director at Taconic Biosciences, to discuss how the shifting techniques and technologies in bioscience affect – and are affected by – mouse models.

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About the Author

William Aryitey

My fascination with science, gaming, and writing led to my studying biology at university, while simultaneously working as an online games journalist. After university, I travelled across Europe, working on a novel and developing a game, before finding my way to Texere. As Associate Editor, I’m evolving my loves of science and writing, while continuing to pursue my passion for gaming and creative writing in a personal capacity.

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