New evidence suggests there’s more to metastasis than MMPs, demanding a therapeutic rethink.
Jonathan James | | Quick Read
Metastasis is the most dangerous step in a cancer’s evolution, yet specific therapies intended to inhibit the process remain elusive. Scientists have long focused on inhibiting matrix metalloproteinases (MMPs) – a family of enzymes that are believed to aid cell migration by degrading the dense network of proteins – called the basement membrane – that surrounds human tissues. Now, a study reported in Developmental Cell suggests there may be far more to the story of metastasis than previously thought (1).
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- LC Kelley et al., “Adaptive F-actin Polymerization and Localized ATP Production Drive Basement Membrane Invasion in the Absence of MMPs.” Dev Cell, 18, 31084-6. [Epub ahead of print] (2019) PMID: 30686527