Monitoring Kinome Adaptations to Therapy using Quantitative High Resolution Mass Spectrometry
June 23, 2016 8:00 AM PDT 11:00 AM EST
Historically, researchers have utilized technologies such as qRT-PCR, Taqman Gene expression assays, western blotting, and liquid chromatography mass spectrometry that allow them to look at single kinases in a relatively linear fashion. Learn how studying the kinome as a whole entity, using additional technologies like quantitative high resolution orbital mass spectrometry, can aide in understanding how tumors may evade current therapies by altering their kinome state. Using this information, learn how clinical translational researchers are investigating new and potentially more effective kinase inhibitor combination therapies for complex diseases like cancer.
Key Learning Objectives:
What you will learn:
- Define methods to study protein kinome “en masse” using chemical proteomics.
- Identify novel kinase inhibitor combinations that overcome drug resistance.
- Explore the function of protein kinases that represent the (un) targeted kinome.
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