A robust mass spectrometer for precision medicine – the Orbitrap Exploris 240 mass spectrometer for large-scale plasma protein profiling

Goal

To demonstrate the reliability and robustness of the Thermo Scientific™ Orbitrap Exploris™ 240 mass spectrometer for large-scale, untargeted plasma protein profiling.

Introduction

Biomarkers are greatly needed for managing patients with diseases and improving efficacy of biotherapeutics. Blood is an ideal biological material for biomarker discovery because its collection can be done routinely and repeatedly in the clinic. With emerging efforts of establishing large biorepositories, research laboratories race to assemble robust and reproducible mass spectrometry-based workflows that can be scaled up to detect disease relevant plasma protein biomarkers, and can be implemented in the clinic to benefit the affected population.