When it comes to prognosis, the mouse models I use to study amyotrophic lateral sclerosis (ALS) are sadly accurate – like their human counterparts with familial ALS, all mice with these mutations die young. After 20 years of trying – and failing – to find a treatment that could extend life, I was close to giving up, until a new drug candidate came along. Then something amazing happened – a mouse lived.
Sitting Down With…John Doench, Associate Director, Genetic Perturbation Platform, Broad Institute, Cambridge, MA, USA.
Researchers dive through genetic “junk” to discover a small protein with lots of heart
A new method could dramatically speed up analysis of nucleic acid thermal behavior
CRISPR has brought gene editing into the mainstream – but where should we draw the line?
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