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Cell & gene therapy

Tools & Techniques Cancer

Building a Better Mousetrap

| Michael Schubert

It’s often difficult to target pancreatic cancer cells while sparing healthy tissue – but a new therapy concept not only makes this possible, but also enhances the potential effectiveness of adjuvant treatments

Tools & Techniques Cancer

An Epigenetic Epiphany

| Michael Schubert

When genetics yielded unsatisfactory answers about pancreatic cancer’s persistent survival, researchers looked beyond the genome – and found telling epigenetic changes

Tools & Techniques Cancer

Breaching Cancer’s Defenses

| Ingunn Stromnes

A new immunotherapy approach shows that engineered T cells are able to penetrate into pancreatic tumors and directly attack the cancer

Tools & Techniques Cancer

(Chemo)resistance Is Futile

| Michael Schubert

The epithelial-to-mesenchymal transition in pancreatic cancer may play a role in its resistance to treatment – and inhibiting it may improve treatment efficacy

Tools & Techniques Cell & gene therapy

Mission: Impossible

| Michael Schubert

Pancreatic cancer is tough to understand, diagnose and treat. Undeterred researchers are on a quest to crack the case.

Tools & Techniques Cell & gene therapy

Image of the Month

| Charlotte Barker

Researchers at MIT have programmed induced pluripotent stem cells to form rudimentary livers, complete with different tissues, by engineering expression of GATA6.

Research Field Cancer

Personalized Medicine × Nanotechnology

| Tamara Minko

The combination of genomic profiling and high-tech targeted drug delivery is opening up a new front in the fight against cancer.

Tools & Techniques Biomedical engineering

Cellular Prostheses for Psoriasis

| James Strachan

Could cell-based synthetic circuits make pills and ointments a thing of the past for chronic disease?

Research Field Cell & gene therapy

Changing the Leopard’s Spots

| James Strachan

Holding back the “guardian of the genome” opens the gates to more efficient transdifferentiation

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