Outside the Lab Informatics

Asking the Ultimate Question

| Michael N. Liebman

In today’s highly competitive academic world, are we losing sight of the real goal of biomedical research in our rush to secure funding and embrace the latest technologies?

Tools & Techniques Cancer

Building a Better Mousetrap

| Michael Schubert

It’s often difficult to target pancreatic cancer cells while sparing healthy tissue – but a new therapy concept not only makes this possible, but also enhances the potential effectiveness of adjuvant treatments

Tools & Techniques Cancer

An Epigenetic Epiphany

| Michael Schubert

When genetics yielded unsatisfactory answers about pancreatic cancer’s persistent survival, researchers looked beyond the genome – and found telling epigenetic changes

Tools & Techniques Cancer

Breaching Cancer’s Defenses

| Ingunn Stromnes

A new immunotherapy approach shows that engineered T cells are able to penetrate into pancreatic tumors and directly attack the cancer

Tools & Techniques Cancer

(Chemo)resistance Is Futile

| Michael Schubert

The epithelial-to-mesenchymal transition in pancreatic cancer may play a role in its resistance to treatment – and inhibiting it may improve treatment efficacy

Tools & Techniques Cell & gene therapy

Mission: Impossible

| Michael Schubert

Pancreatic cancer is tough to understand, diagnose and treat. Undeterred researchers are on a quest to crack the case.

Disease Area Drug discovery

Finding HIV’s Achilles’ Heel

| Timothy Fouts

The human immunodeficiency virus has evaded the best efforts of vaccine developers for over three decades.

Research Field Cancer

No Biomarker, No Trial?

| James Ritchie, Sidath Katugampola, Paul Jones

The vast majority of experimental cancer drugs fail during the later stages of clinical development

Disease Area Personalized medicine

Engineering Better Health

| Julian Solway

Sitting Down With… Julian Solway MD, Walter L. Palmer Distinguished Service Professor - Medicine and Pediatrics, Director - Institute for Translational Medicine, Dean for Translational Medicine, University of Chicago, USA.

Outside the Lab Professional development

Fresh-(Faced) Funding

| Robin Barr

Making grant application processes tougher can have an unexpected and dramatic effect on the demographics of applicants. Let’s not force young investigators to fall at the first hurdle.

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