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Drug discovery

Research Field Cardiovascular

Wait and iPSC

| William Aryitey

iPSCs could protect patients by predicting drug-induced cardiotoxicity

Research Field Drug discovery

Arresting ALS

| Joe Beckman

When it comes to prognosis, the mouse models I use to study amyotrophic lateral sclerosis (ALS) are sadly accurate – like their human counterparts with familial ALS, all mice with these mutations die young. After 20 years of trying – and failing – to find a treatment that could extend life, I was close to giving up, until a new drug candidate came along. Then something amazing happened – a mouse lived.

Research Field Cancer

Cancer Static Shock

| James Strachan

Are the metrics used to measure cancer drug efficacy inherently flawed?

Tools & Techniques Drug discovery

A Story of Shared Science and Solutions

| Niclas Nilsson

Pharma companies are notoriously protective of their intellectual property, so it’s a big deal to open up and give knowledge away for free.

Research Field Cancer

Laser Focus on Brain Cancer

| William Aryitey

How can we get cytotoxic drugs through the blood–brain barrier – without permanent damage?

Research Field Analytical science

Fragment Screening at (Almost) the Speed of Light

| Frank von Delft

The XChem facility offers drug discovery scientists streamlined, highly sensitive fragment screening, by harnessing the power of synchrotron light.

Research Field Analytical science

The Shape of Proteins to Come

| Charlotte Barker

A new technique allows scientists to see conformational changes caused by ligand binding in real time, opening up new screening options for drug discovery.

Research Field Cardiovascular

State-of-the-Heart Tissue Models

| John Ahrens and Joseph C. Wu

A decade after Shinya Yamanaka brought us induced pluripotent stem cells, our ability to generate an endless supply of human heart cells is being put to good use in research and development.

Disease Area Drug discovery

Finding HIV’s Achilles’ Heel

| Timothy Fouts

The human immunodeficiency virus has evaded the best efforts of vaccine developers for over three decades.

Research Field Cancer

No Biomarker, No Trial?

| James Ritchie, Sidath Katugampola, Paul Jones

The vast majority of experimental cancer drugs fail during the later stages of clinical development

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