A new technique allows scientists to see conformational changes caused by ligand binding in real time, opening up new screening options for drug discovery.

Hundreds of potential drug targets have been discovered by researchers mapping pain pathways, but clinical trials have proved unsuccessful in most cases. Can we pick our way through the translational maze to find much-needed new analgesics?

On each side of the brain stem, a florescent green marker illuminates the two networks of 200 neurons that control the sighing reflex

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The true mission of translational science is to take new medicines and diagnostics from bench to bedside – and beyond

Researchers at MIT have programmed induced pluripotent stem cells to form rudimentary livers, complete with different tissues, by engineering expression of GATA6.

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Could the lab rat be heading for retirement? A new breed of in vitro tissues and organs are being engineered to replace animal models – and the developers aim to make them accessible to all.

Sitting Down With… Jennifer Grandis, Professor, Department of Otolaryngology – Head and Neck Surgery, Associate Vice Chancellor – Clinical and Translational Research, University of California, San Francisco, USA.

Our understanding of the mechanisms that trigger Alzheimer’s disease is growing fast, but many secrets still lurk in the shadowy recesses of the brain.