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As the judges deliberate over this year's winner, we speak with three of the top-placed entrants from the 2015 Humanity in Science Award.

Developing a dengue vaccine has been like a 20-year game of Snakes and Ladders – but in this game, there are four billion winners, as the prize could help protect half the world’s population.

The XChem facility offers drug discovery scientists streamlined, highly sensitive fragment screening, by harnessing the power of synchrotron light.

A new technique allows scientists to see conformational changes caused by ligand binding in real time, opening up new screening options for drug discovery.

Shotgun sequencing is a powerful tool in microbial genomics, but viral genomes have proven tough to crack.

How and what we measure in animal studies of pain has huge implications for clinical translation.

Does pain in early childhood have a profound impact later in life?

Chronic pain is the most prevalent and expensive public health problem in the developed world, but as a society we consistently fail to recognize the scale of the public health issue.

Basic and clinical researchers must join forces to fight pain.

Hundreds of potential drug targets have been discovered by researchers mapping pain pathways, but clinical trials have proved unsuccessful in most cases. Can we pick our way through the translational maze to find much-needed new analgesics?