Advanced mass spectrometry uncovers a tiny protein with important implications
Joanna Cummings |
Meet NoBody (non-annotated P-body dissociating polypeptide): a new, functional human microprotein, discovered and characterized by biochemists using cutting-edge gene sequencing and proteomics technologies at Yale University (1).
The team examined myeloid leukemia cells, first removing larger proteins, then using liquid chromatography-mass spectrometry (LC-MS) based proteomics to uncover the amino acid sequence of each of the more than 400 microproteins that remained. Having discovered a veritable treasure trove of previously unknown proteins, the researchers set out to find out their function (if any) in the body.
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