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Tools & Techniques Analytical science, Omics

NoBody’s Fool

Meet NoBody (non-annotated P-body dissociating polypeptide): a new, functional human microprotein, discovered and characterized by biochemists using cutting-edge gene sequencing and proteomics technologies at Yale University (1).

The team examined myeloid leukemia cells, first removing larger proteins, then using liquid chromatography-mass spectrometry (LC-MS) based proteomics to uncover the amino acid sequence of each of the more than 400 microproteins that remained. Having discovered a veritable treasure trove of previously unknown proteins, the researchers set out to find out their function (if any) in the body.

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About the Author

Joanna Cummings

A former library manager and storyteller, I have wanted to write for magazines since I was six years old, when I used to make my own out of foolscap paper and sellotape and distribute them to my family. Since getting my MSc in Publishing, I’ve worked as a freelance writer and content creator for both digital and print, writing on subjects such as fashion, food, tourism, photography – and the history of Roman toilets. Now I can be found working on The Analytical Scientist, finding the ‘human angle’ to cutting-edge science stories.

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