A tool to predict racemization could help prevent drug discovery dead ends
Roisin McGuigan |
Many drugs are chiral molecules, which means that they have the potential to “flip” and exist as different enantiomers – non-superimposable mirror images of the original molecule with an identical chemical structure. In some cases, this flipping behavior can occur when an enantiomerically pure drug enters the body – a process known as racemization. Recent research aims to predict racemization (1), so we spoke to co-author Niek Buurma from Cardiff University’s School of Chemistry to discover more about the dangers of mirror molecules – and a new tool to remedy the problem.
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