Cookies

Like most websites The Translational Scientist uses cookies. In order to deliver a personalized, responsive service and to improve the site, we remember and store information about how you use it. Learn more.
Disease Area Pain & critical care

Hurt Blocker

“There’s a tremendous need to better understand the molecular mechanisms responsible for pain,” says Zachary Campbell, Assistant Professor at the University of Texas at Dallas. His team has been delving into the chemical cascade that leads to pain perception – and aims to intervene by inhibiting a key protein – Poly(A)-binding protein (PABP) – using a synthetic RNA mimic.

The result was reduced pain sensitization in mice (1). PABP binds to the Poly(A) tail of messenger RNA during the formation of multiprotein complexes that regulate transcription during protein synthesis. Previous studies have found that one of those complexes, the cap-binding complex, is a key player in pain sensitization. The researchers used functional genomics to examine the specificity of PABP, and then created a chemically stabilized RNA substrate that could bind PABP and inhibit translation, which prevents the formation of the cap-binding complex – and cuts the pain response.

Enjoy our FREE content!

Log in or register to read this article in full and gain access to The Translational Scientist’s entire content archive. It’s FREE and always will be!

Login if you already created an account

Or register now - it’s free and always will be!

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
Register

Or Login as a Guest or via Social Media

About the Author

James Strachan

Over the course of my Biomedical Sciences degree it dawned on me that my goal of becoming a scientist didn’t quite mesh with my lack of affinity for lab work. Thinking on my decision to pursue biology rather than English at age 15 – despite an aptitude for the latter – I realized that science writing was a way to combine what I loved with what I was good at.
From there I set out to gather as much freelancing experience as I could, spending 2 years developing scientific content for International Innovation, before completing an MSc in Science Communication. After gaining invaluable experience in supporting the communications efforts of CERN and IN-PART, I joined Texere – where I am focused on producing consistently engaging, cutting-edge and innovative content for our specialist audiences around the world.

Related Solutions

Disease Area

See how droplets are guiding precision medicine

| Contributed by Bio Rad

Disease Area

Improving Absorption Measurements through Light Source Selection

| Contributed by Ocean Optics

Newsletter

Send me the latest from The Translational Scientist.

Sign up now

Related Articles

Disease Area

Resisting Arrest

| Roisin McGuigan

Disease Area

Pain and Vision Gain

| Roisin McGuigan

Disease Area

Sepsis and Serendipity

| Roisin McGuigan

Most Popular

Register here

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts

Register