Tools & Techniques Neuroscience, Imaging

Image of the Month

Credit: Tyler Stradleigh, Nord Lab, UC Davis Center for Neuroscience.


A recent study has used mice to gain insight into changes in the brain seen in autism spectrum disorder (ASD). The paper from University of California Davis describes a mutation in the Chd8 gene that causes increased brain size, or megalencephaly, in mouse cortex, a condition also present in people with ASD. Antibodies against Tbr1 (green) and Ctip2 (red) display distinct laminar distributions within the cortex and differential regional expression in the hippocampus of a juvenile mouse brain.

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  1. AL Gompers et al., “Germline Chd8 haploinsufficiency alters brain development in mouse”, Nat Neurosci, [Epub ahead of print] (2017). PMID: 28671691.
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Charlotte Barker

“As Editor of The Translational Scientist, I’m working closely with our audience to create vibrant, engaging content that reflects the hard work and passion that goes into bringing new medicines to market. I got my start in biomedical publishing as a commissioning editor for healthcare journals and have spent my career covering everything from early-stage research to clinical medicine, so I know my way around. And I can’t think of a more interesting, challenging or important area to be working in.”

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