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Research Field Neuroscience

Seeds of Alzheimer's

| William Aryitey

Another study supports potential surgical transmission of amyloid beta plaques – but the discussion is far from closed

Disease Area Immunology

Image of the Month

| Charlotte Barker

On each side of the brain stem, a florescent green marker illuminates the two networks of 200 neurons that control the sighing reflex

Outside the Lab Infectious diseases

Video: Inside The Translational Scientist

| Charlotte Barker

Want a lightning-fast tour of the latest issue? Take a look at our new video sneak preview.

Research Field Cardiovascular

State-of-the-Heart Tissue Models

| John Ahrens and Joseph C. Wu

A decade after Shinya Yamanaka brought us induced pluripotent stem cells, our ability to generate an endless supply of human heart cells is being put to good use in research and development.

Research Field Cancer

Unlocking Checkpoint Inhibition

| Eric Rubin, David Matthews

Like many drugs today, pembrolizumab (Keytruda) was the result of a group effort. Here, we catch up with two scientists who shaped the destiny of the biotherapeutic at very different stages in its development.

Outside the Lab Informatics

Asking the Ultimate Question

| Michael N. Liebman

In today’s highly competitive academic world, are we losing sight of the real goal of biomedical research in our rush to secure funding and embrace the latest technologies?

Tools & Techniques Cancer

Building a Better Mousetrap

| Michael Schubert

It’s often difficult to target pancreatic cancer cells while sparing healthy tissue – but a new therapy concept not only makes this possible, but also enhances the potential effectiveness of adjuvant treatments

Tools & Techniques Cancer

An Epigenetic Epiphany

| Michael Schubert

When genetics yielded unsatisfactory answers about pancreatic cancer’s persistent survival, researchers looked beyond the genome – and found telling epigenetic changes

Tools & Techniques Cancer

Breaching Cancer’s Defenses

| Ingunn Stromnes

A new immunotherapy approach shows that engineered T cells are able to penetrate into pancreatic tumors and directly attack the cancer

Tools & Techniques Cancer

(Chemo)resistance Is Futile

| Michael Schubert

The epithelial-to-mesenchymal transition in pancreatic cancer may play a role in its resistance to treatment – and inhibiting it may improve treatment efficacy

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