Weathering the Cytokine Storm
THC halts the immune cascade that causes acute respiratory distress syndrome in mice
Charlotte Barker |
A preclinical study showed that administration of THC was highly effective in preventing chemically induced acute respiratory distress syndrome (ARDS) in a mouse model (1).
The researchers exposed mice to enterotoxin B, which usually leads to a cytokine storm that causes the immune system to attack lung tissues. The result? Rapid onset of ARDS and death within a few days. In fact, all of the mice in the untreated control group grew so sick they had to be euthanized.
However, when the researchers gave THC immediately after exposure to the toxin none of the mice developed symptoms of ARDS and 100 percent survived.
These dramatic results have raised speculation that THC might help patients who develop ARDS as a result of COVID-19; however, the research is preliminary at this stage, with no guarantee it will translate from mice to humans.
Subscribe to The Translational Scientist Newsletters
- A Mohammed et al., Front Pharmacol, 11, 893 (2020). DOI: 10.3389/fphar.2020.00893