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Research Field Animal models, Drug discovery, Biomedical engineering

Skin in the Game

Genoskin – a French National Center for Scientific Research (CNRS) spinoff – believes there is a better alternative to animal testing when it comes to dermatological and cosmetic research: donated human skin, which it collects from surgical procedures. Keeping the skin ‘alive’ using an ex vivo culture system, the company is able to provide skin samples in the form of slide sections, frozen tissue, or epidermal to hypodermal sections.

“I have previously worked with transgenic and knockout mice to investigate the function of a particular gene in skin development,” explains says Pascal Descargues, CEO of Genoskin. “The mouse models were very useful in discovering new molecular pathways, but we were not able to confirm the results for humans because we were missing key comparable elements. Furthermore, we found that a mouse model reproducing the skin disorder Netherton Syndrome could not be used to screen drugs at all since the disease is lethal for mice.”

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About the Author

William Aryitey

My fascination with science, gaming, and writing led to my studying biology at university, while simultaneously working as an online games journalist. After university, I travelled across Europe, working on a novel and developing a game, before finding my way to Texere. As Associate Editor, I’m evolving my loves of science and writing, while continuing to pursue my passion for gaming and creative writing in a personal capacity.

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