Cookies

Like most websites The Translational Scientist uses cookies. In order to deliver a personalized, responsive service and to improve the site, we remember and store information about how you use it. Learn more.
Research Field Neuroscience, Genetics

Searching for Schizophrenia

With symptoms that vary in degree or frequency and significantly overlap with other conditions, mental illness can be hard to identify – let alone definitively diagnose. But for at least one such disorder, scientists from Sweden’s Karolinska Institutet are tackling the problem with a combinatorial approach.

The researchers blended their understanding of brain cellular taxonomy (the different cells of the brain and the genes used by each cell type) with the genomic loci implicated in schizophrenia in a successful attempt to identify which specific cell types might be associated with the condition (1). Their discovery? That the genes commonly altered in schizophrenia are consistently associated with pyramidal cells, medium spiny neurons (MSNs), and some types of interneurons. Furthermore, not all mutations are equal; the changes that affect MSNs are separate to those affecting pyramidal cells and interneurons, meaning that each cell type may play a different role in the disease process.

Enjoy our FREE content!

Log in or register to read this article in full and gain access to The Translational Scientist’s entire content archive. It’s FREE and always will be!

Login if you already created an account

Or register now - it’s free and always will be!

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
Register

Or Login as a Guest or via Social Media

About the Author

Michael Schubert

While obtaining degrees in biology from the University of Alberta and biochemistry from Penn State College of Medicine, I worked as a freelance science and medical writer. I was able to hone my skills in research, presentation and scientific writing by assembling grants and journal articles, speaking at international conferences, and consulting on topics ranging from medical education to comic book science. As much as I’ve enjoyed designing new bacteria and plausible superheroes, though, I’m more pleased than ever to be at Texere, using my writing and editing skills to create great content for a professional audience.

Related Solutions

Research Field

Dental Curing Lights: Clinical Reality

| Contributed by Ocean Optics

Research Field

Measuring DNA Absorbance with the STS-UV

| Contributed by Ocean Optics

Newsletter

Send me the latest from The Translational Scientist.

Sign up now

Related Articles

Research Field

The Power To Change Lives

| Stephanie Sutton

Research Field

Not Immune to Damage

| Ruth Steer

Research Field

Better Biomarkers for AD R&D

| Carlo Medici

Most Popular

Register here

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts

Register