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Research Field Imaging, Neuroscience

“Miami, We Have a Problem”

Since that “one small step,” mankind has made giant leaps forward in space science. Today, astronauts regularly check in and out of the International Space Station (ISS), and the time they spend there is becoming longer and longer. But extended spaceflight brings with it a specter: visual impairment due to intracranial pressure (VIIP) syndrome, giving space agencies another vital mission… to characterize the syndrome and to figure out how to protect their astronauts from it.

VIIP is thought to result from microgravity-induced fluid shift, with symptoms being reported by up to two-thirds of astronauts during or after space flight (1), (2). But to date, the actual etiology of VIIP syndrome has not been defined. Now, a team from the University of Miami who have been studying changes in eye shape and cerebrospinal fluid (CSF) volume in astronauts, have provided the first quantitative evidence for a direct role of CSF in spaceflight-induced ocular changes (Figure 1) (3). Noam Alperin, Professor of Radiology and Biomedical Engineering at University of Miami Miller School of Medicine, and lead author of the study, tells us more…

Figure 1. Study design and summary of key results. The team used quantitative imaging algorithms to analyze MRI scans and establish correlation between changes in CSF volume and ocular structure (3).


Our group has been investigating the CSF system for a long time, and we’d developed a method to measure intracranial pressure (ICP) non-invasively by magnetic resonance imaging (MRI). In 2010, I received a call from NASA, “Miami, we have a problem.”


We installed a protocol in their MRI scanner that’s located near the Houston Space Center. For four years, we studied astronauts before and after space flights, collecting data from short-duration and long-duration astronauts. The algorithm we’ve developed to assess morphological changes provides a quantitative measure, and is much more accurate, reliable and reproducible than previous methods which involved “eyeballing the eyeball.”


We saw that most astronauts developed VIIP to a certain severity by six months. From studying short-duration astronauts who have been in spaceflight for two weeks, we know that VIIP starts after a much longer duration than this – I would say after several months of time in space and we expect that the longer the flight, the worse the deformations.

What’s next?

We’re already starting to use our approach to study glaucoma, and we’ve done a lot of work that will hopefully be published soon. We think our method of measuring CSF volume is a consistent way to assess the balance between the eye and the brain. We’ll also continue working with NASA to examine the effects of “head down tilt” on the globe of the eye. In this study, subjects will spend 30 days in bed with a head-down tilt of six degrees to simulate the movement of fluids from the legs to the head, and we’ll measure and quantify the deformation that occurs.

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  1. National Aeronautics and Space Administration: Human Research Program, Human Health Countermeasures Element, “Evidence Report: Risk of spaceflight-induced intracranial hypertension and vision alterations”, July 12, 2012. Available at: Accessed December 13, 2016.
  2. TH Mader et al., “Optic disc edema, globe flattening, choroidal folds, and hyperopic shifts observed in astronauts after long-duration space flight”, Ophthalmol, 118, 2058–2069 (2011). PMID: 21849212.
  3. N Alperin et al., “Role of cerebrospinal fluid in spaceflight-induced visual impairment and ocular changes”. Presented at the Radiological Society of North America (RSNA) annual meeting, Chicago, November 28, 2016. Presentation # SSC11-04.
About the Author
Ruth Steer

Following my journey through academia, I entered the world of scientific writing and never looked back. After several years of working as a medical writer – where I developed a wide range of skills in healthcare publications and communications – I took the opportunity to stretch my creative and journalistic muscles and joined Texere Publishing. Working as Editor on The Ophthalmologist allows me to nurture my skills in scientific writing – and explore the dynamic world of ophthalmology – all within an innovative and exciting company.

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