Neurons Under (Astrocytic) Attack
Could manipulation of micro-RNA cross-talk between astrocytes and neuronal cells yield a new therapeutic avenue for ALS?
Jonathan James | | Quick Read
Scientists have been aware for more than a decade that astrocytes play a key role in the pathology of amyotrophic lateral sclerosis (ALS). Exactly how they contribute to neuronal death – a key feature of the condition – has remained a mystery. Many have focused on the catalog of molecules that astrocytes produce and exchange with neuronal cells. Now, a paper published in EBioMedicine describes a pathway for this process – at least in ALS patients carrying a specific genetic mutation (1)
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