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Tools & Techniques Drug delivery, Cancer, Imaging

Heavy Metal Wonder

After the approval of cisplatin in the late 1970s, scientists struggled to replicate the success with other heavy metal-based chemotherapeutics. But, more recently, the field has seen somewhat of a resurgence with new metal-based compounds boasting distinct modes of action (1). Now, a paper in the international edition of the German journal Angewandte Chemie highlights a new photosensitizer with iridium at its core (2).

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  1. U Ndagi et al., “Metal complexes in cancer therapy – an update from a drug design perspective.” Drug Des Devel Ther. 11, 599-616. (2017) PMID: 28424538.
  2. P Zhang et al., “Nucleus-Targeted Organoiridium-Albumin Conjugate for Photodynamic Cancer Therapy.” Angew Chem Int Ed Engl. [Epub ahead of print] (2018) PMID: 30552796.
  3. J Trachtenberg et al., “Vascular targeted photodynamic therapy with palladium-bacteriopheophorbide photosensitizer for recurrent prostate cancer following definitive radiation therapy: assessment of safety and treatment response”, J Urol. 178, 1974-1979 (2007). PMID: 17869307.
  4. T Gheewala, T Skwor & G Munirathinam, “Photosensitizers in prostate cancer therapy”, Oncotarget. 8, 30524-30538 (2017). PMID: 28430624.

About the Author

Jonathan James

As an assistant editor for The Translational Scientist, I can combine two of my passions; translational science research and science communication. Having thrown myself into various editing and other science communication gigs whilst at University I came to realise the importance of good quality content that delivers in an exciting and engaging way.

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