Heavy Metal Wonder
An iridium-based photodynamic drug accumulates in cancer cell nuclei – and destroys them from within
Jonathan James | | Quick Read
After the approval of cisplatin in the late 1970s, scientists struggled to replicate the success with other heavy metal-based chemotherapeutics. But, more recently, the field has seen somewhat of a resurgence with new metal-based compounds boasting distinct modes of action (1). Now, a paper in the international edition of the German journal Angewandte Chemie highlights a new photosensitizer with iridium at its core (2).
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- U Ndagi et al., “Metal complexes in cancer therapy – an update from a drug design perspective.” Drug Des Devel Ther. 11, 599-616. (2017) PMID: 28424538.
- P Zhang et al., “Nucleus-Targeted Organoiridium-Albumin Conjugate for Photodynamic Cancer Therapy.” Angew Chem Int Ed Engl. [Epub ahead of print] (2018) PMID: 30552796.
- J Trachtenberg et al., “Vascular targeted photodynamic therapy with palladium-bacteriopheophorbide photosensitizer for recurrent prostate cancer following definitive radiation therapy: assessment of safety and treatment response”, J Urol. 178, 1974-1979 (2007). PMID: 17869307.
- T Gheewala, T Skwor & G Munirathinam, “Photosensitizers in prostate cancer therapy”, Oncotarget. 8, 30524-30538 (2017). PMID: 28430624.