Research Field Neuroscience, Microbiology

Video of the Month

We’ve previously discussed the vast potential of tapping into the gut microbiome and how delving into its intricacies can lead to new therapeutics (1). Now, researchers at Johns Hopkins have furthered our knowledge with their discovery of the birth- and death-cycle of gut neurons in adult mice. The work contradicts the previous belief that gut neurogenesis rarely occurs – if at all – in adult tissue (2).

The video below shows a 3D generated image of neural precursor cells (green), blood vessels (blue), and cell nuclei (grey) of a mouse gut.

Credit: Pankaj Jay Pasricha lab/Johns Hopkins Division of Gastroenterology.

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  1. K Dabbagh, “Medicine Meets the Microbiome”, The Translational Scientist, 4, 18–25 (2016). Available at: bit.ly/2pR1TR0.
  2. S Kulkarni et al., “Adult enteric nervous system in health is maintained by dynamic balance between neuronal apoptosis and neurogenesis”, PNAS, [Epub ahead of print] (2017).
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